Al most every drug is able to affect pharmacological activity of one or the other drug, we are providing in brief some basic mechanisms by which drug interaction occurs.
1. Modifying metabolism of a particular drug
A particular drug can induce enzymes responsible for metabolic degradation of other drug; this is due to induction or enhancement of degradative enzyme system which is already in place like liver or peripheral enzymes.
2. Modifying absorption of a drug
A drug can create an environment which may result in increased or decreased absorption of a particular drug.
3. Modifying distribution of a drug in body :
A drug can induce or enhance enzymes or proteins which binds other drug so that the drug is not free to exert the desired action at particular site.
4. Modifying Metabolism and Biotransformation of a drug:
Particular drug may interfere in biotransformation and metabolism of a drug making it difficult to get elimination or degradation or may result in potentiating of activity or reduction of activity due to improper conversion in to active form.
5. Modifying Elimination of a drug from body
A particular drug may modify elimination by modifying the PH so that the drug is eliminated faster or it is reabsorbed.
6. Potentiating Agonistic and antagonistic actions
A drug can potentiate a particular pharmacological action; by increasing each others activity one or the other drug may potentiate activity of each other and resulting in a synergistic action. which may cause harmful effect.
A drug may potentiate antagonistic action of other drug by virtue of several mechanisms like inhibition enzyme in the critical path way of degradation.
Some drug interactions is intentionally made use for enhancing activity of a particular drug or reducing activity of other drug.
Do you know now this website has become a most popular and most referred website in pharmaceutical industry and pharmaceutical companies all over the world ,for almost all topics related to Pharmaceutical Manufacturing , Pharmaceutical Regulatory Affairs and Good Manufacturing Practice and latest news and new drugs developments.
What is What is 510(k) Clearances ?
What is 510(k) Clearances, Premarket Notification for medical devices – PMN or 510(k)
Antibiotic Definition and classification
Antibiotic resitance and Antibiotic resistance mechanism
Vitamin D Details on FDA cautions on accurate dosage of Vitamin D
What is an antibody? what is monoclonal and polyclonal antibodies?
Enzyme linked immunosorbent assay ELISA
Pharmaceutical Aseptic Manufacturing Process Terms , Terminology and Definitions.
Here are some articles which will be useful for you in further understanding of aspects of sterile dosage form manufacturing and regulatory affairs and good manufacturing practice in
Types of validations in pharmaceutical manufacturing
Requirements of documents for validation of sterilisation process
How to investigate OOS out of specification results
Determination of Phenol coefficient of a disinfectant
Time limitations in sterile pharmaceuticals processing
Aspects of validation of manufacturing process in sterile pharmaceuticals
Controlling Pyrogens in injectable dosage forms
Media fill run process simulation aspects Validation of Aseptic Process and Sterilisation
New Drug Application (NDA) how to make a New Drug Application (NDA) to US FDA
Abbreviated New Drug Application (ANDA) What is ANDA , detaied information about ANDA preparation and submission to US FDA
How to make Investigational New Drug (IND) Application to US FDA
Drug applications submission to us fda Over the counter Drugs OTC drugs
BIOAVAILABILITY AND BIOEQUIVALENCE REQUIREMENTS
Electronic record in pharmaceutical manufacturing industry
Good manufacturing practice in pharmaceutical industry
Pharmaceutical industry pharmaceutical companies and FDA latest updates
Here is an interesting article on world wide pharmaceutical industry
Article on Pharmaceutical Industry pharmaceutical industry
Here are some interesting articles on Quality assurance systems for pharmaceutical company
1.Quality assurance in pharma industry
2.Quality by designe concept for pharmaceutical industry
3.Quality by designe concept in pharmaceutical industryan explanation