Protopam Chloride (pralidoxime chloride) is now approved by US FDA for pediatric use of chemical poisoning treatment.
The United .States. F D A has approved new drug Protopam Chloride (pralidoxime chloride) for pediatric use .Protopam Chloride (pralidoxime chloride) is a drug which is used in the treatment of poisoning of organophosphate pesticides and chemicals (e.g., nerve agents) . US FDA approved has this drug for intravenous (IV) or intramuscular (IM) injections routes of administartion.
Although the drug was in use for treatment for poisoning in pediatric patients in emergency situations even before US FDA approved this drug. Approval of this drug by US FDA will present Improved drug’s labeling with new dosing information to treat children’s, also it will provide health care professionals better guidance about better and safe usage of this drug in children’s .Proper directions in label, in an emergency situations for use of this drug in intramuscular or IV route will prove helpful to healthcare professionals.
Organophosphate pesticides OP, are esters of phosphoric acid , owing to similarity to the functional structure of acetyle choline OP block irreversibly enzyme acetylcholinesterase (AChE) in nerve cells , and this become fatal and may cause deth in severe poisoning.
OP are used in the farm as pesticides by professional exterminators.
Symptoms of OP poisoning, includes salivation a runny nose, lacrimation, vomiting, Urinary incontinence (UI) Serious symptoms OP poisoning difficulty breathing, weakness and convulsions.
When chemical poisoning is suspected, medical attention should be sought immediately and the local poison control center should be contacted by dialing 800-222-1222, nationwide.
Information about Protopam Chloride:
It is used to to treat poisoning by organophosphates or acetylcholinesterase inhibitors (nerve agents), in conjunction with atropine and diazepam. Earlier in 1964 FDA approved Protopam Chloride for treating various pesticide and chemical poisoning in adults. The drug works as an antidote to pesticides and chemicals of the organophosphate class by slowing the attachment of the chemical to nerve endings, it binds enzyme enzyme acetylcholinesterase (AChE) reversibly there by reduces the effect of OP.
Protopam Chloride Adverse reactions:
Increased heart rate. Increased blood pressure, blurred vision, double vision, dizziness, headache, drowsiness, nausea, difficulty breathing.
Do you know now this website has become a most popular and most referred website in pharmaceutical industry and pharmaceutical companies and pharmaceutical manufacturers from all over the world ,for almost all topics related to Pharmaceutical Manufacturing , Pharmaceutical Regulatory Affairs and Good Manufacturing Practice for Pharmaceutical Manufacturing (c GMP guidelines ) and latest news and new drugs developments.
You may also like following articles
Whar is Referance Listed Drug ? ( RLD )
What is Pharmaceutical Equivalents
What is Pharmaceutical Alternatives
What is Therapeutic Equivalents
Do Physical properties contribute to drug activity.
What is drug receptor , How a drug resistance occurs
Mechanism of drug resistance
What is drug interaction
Drug interaction, and its examples
What is first pass metabolism of a drug
What is What is 510(k) Clearances ?
What is 510(k) Clearances,
Premarket Notification for medical devices – PMN or 510(k)
What is a drug interaction
Examples of drug interactions
Antibiotic Definition and classification
Antibiotic resitance and Antibiotic resistance mechanism
Antioxidants food suppliments
Vitamin D Details on FDA cautions on accurate dosage of Vitamin D
What is an antibody? what is monoclonal and polyclonal antibodies?
Terminologies In vaccine Production
Multi stage testing of Virus vaccine production
Testing of vaccines at different stages of production
TESTING FOR ADVENTITIOUS AGENTS CELL PROPERTIES IN VIRAL VACCINE PRODUCTION
Enzyme linked immunosorbent assay ELISA
Raido Immuno assay
Pharmaceutical Aseptic Manufacturing Process Terms , Terminology and Definitions.
Here are some articles which will be useful for you in further understanding of aspects of sterile dosage form manufacturing and regulatory affairs and good manufacturing practice in
Types of validations in pharmaceutical manufacturing
Requirements of documents for validation of sterilisation process
How to investigate OOS out of specification results
Determination of Phenol coefficient of a disinfectant
Cleen Room Classification
Time limitations in sterile pharmaceuticals processing
Aspects of validation of manufacturing process in sterile pharmaceuticals
Controlling Pyrogens in injectable dosage forms
Media fill run process simulation aspects Validation of Aseptic Process and Sterilisation
New Drug Application (NDA) how to make a New Drug Application (NDA) to US FDA
Abbreviated New Drug Application (ANDA) What is ANDA , detaied information about ANDA preparation and submission to US FDA
How to make Investigational New Drug (IND) Application to US FDA
Drug applications submission to us fda Over the counter Drugs OTC drugs
BIOAVAILABILITY AND BIOEQUIVALENCE REQUIREMENTS
Electronic record in pharmaceutical manufacturing industry
Good manufacturing practice in pharmaceutical industry
Pharmaceutical industry pharmaceutical companies and FDA latest updates
Here is an interesting article on world wide pharmaceutical industry and making a carrier in one of pharmaceutical companies article on Pharmaceutical Industry pharmaceutical industry
Find a Job in Pharmaceutical Company
To Find Pharmaceutical jobs and make a Pharmaceutical careers see here pharmaceutical companies
Here are some interesting articles on Quality assurance systems for pharmaceutical company
1.Quality assurance in pharma industry
2.Quality by designe concept for pharmaceutical industry
3.Quality by designe concept in pharmaceutical industryan explanation