Targeted Drug Delivery System using Nanoparticles.
Even with the advances in medicine still there are few bacterial and fungal infection which are difficult to treat as the drugs available do not always work against them, or the drugs themselves prove more toxic to body cells than to infecting microorganism, due to higher doses requirement, one of such is microbe is Staphylococcus aureus.
Resistant form of Staphylococcus aureus bacterial infection do not respond to antibiotics available for its treatment , penicillin and methecilline, (Methecilline resistant Staphylococcus aureus .. MRSA), also some drug resistant fungal infection become life threatening just because of weaker immune system as in the case of HIV and cancer. Targeted Drug Delivery System Nanoparticles
Staphylococcus aureus, bacteria is highly pathogenic typically it is observed as boils over skin and if untreated causes serious infection of vital organs toxic shock syndrome causing multiple organ failure. Its infection spread contagiously from one infected person to other through food and water, and unhygienic surfaces in hospitals.
Medical Nanotechnology research for treatment MRSA.
Nanoparticles of terephthalate (PET) are developed by IBM and Institute of Bioengineering and Nanotechnology, which can be formulated in to various dosage form like topical gels and intravenous injection, these nanoparticles are biodegradable and nontoxic, they can carry a drug and precisely attack to bacterial or fungal cell and deliver the drug in higher concentration to the point of action over bacterial cell. It can be very useful in disinfection and treatment of bacterial and fungal infections as that in athletes foot, and MRSA.
Nanoparticles developed from terephthalate (PET) are biodegradable and nontoxic and are negatively charged, which make them good carrier of antibiotics, the negative charge over them help nanoparticles to move towards and attach to bacterial or fungal cell precisely.
Staphylococcus aureus produce endotoxins, capable of destroying blood cells. It produce enzyme hyaluronidase, staphylokinase, lipase which can dissolve tissue. It also produces enzyme coagulase which help bacteria by forming clot of blood cells where in bacterial cells are harbored and protected from WBC neutrophiles phagocytosis.