Novel use of Beta Cyclodextrin , it will be directly delivered in brain to save life of twin girls suffering from serious neurological disease
A Pharmaceutical exceipent Beta Cyclodextrin being used in a life saving treatment
Beta Cyclodextrin’s unique properties , we have already discussed these properties in our earlier post .
US FDA has first time ever in history has approved an IND where beta cyclodextrin will be delivered directly in to brain for treating two tween girls suffering from Niemann Pick Type C Disease with the hope of saving their life.
Beta Cyclodextrin a sugar polymer which is used in pharmaceuticals food and cosmetics in many form to make a novel drug delivery systems to make an drug readily absorbable by making a drug otherwise poor soluble in to a freely soluble drug in biological membranes.
Beta Cyclodextrin will be utilized in providing a life saving treatment at Children’s Hospital Oakland California. Two tween girls are suffering from Niemann Pick Type C Disease Known as “childhood Alzheimer’s a neurological disease condition which causes severe dementia and other debilitating symptoms in children, Doctors will be administering Beta Cyclodextrin Trappsol® Cyclo™ (Hydroxypropyl Beta Cyclodextrin or HPßCD) into the brains of six year old identical twin girls, in an attempt to arrest a progressive and fatal neurological condition.
Earlier doctors administered Beta Cyclodextrin Trappsol® Cyclo™ in to bloodstreams of these tweens but Beta Cyclodextrin did not cross the blood brain barrier , but did showed some improvement from ataxia , hence to make Cyclodextrin Trappsol® Cyclo available to tissue in brain , Doctors are going to deliver Beta Cyclodextrin Trappsol® Cyclo directly in to brain.
Beta Cyclodextrin is rapidly removed out from body after injection , but its property to form a soluble complex with other peptides and lipids will take away toxic molecules responsible for progression of Niemann Pick Type C Disease out of brain, we fell doctors will be successful in their goal.
One behalf of all readers of this blog we pray to God to make these doctors successful.
=====================================================================================================
Do you know now this website has become a most popular and most referred website in pharmaceutical industry and pharmaceutical companies and pharmaceutical manufacturers from all over the world ,for almost all topics related to Pharmaceutical Manufacturing , Pharmaceutical Regulatory Affairs and Good Manufacturing Practice for Pharmaceutical Manufacturing (c GMP guidelines ) and latest news and new drugs developments.
=====================================================================================================
You may also like following articles
Whar is Referance Listed Drug ? ( RLD )
What is Pharmaceutical Equivalents
What is Pharmaceutical Alternatives
What is Therapeutic Equivalents
Do Physical properties contribute to drug activity.
What is drug receptor , How a drug resistance occurs
Drug interaction, and its examples
What is first pass metabolism of a drug
What is What is 510(k) Clearances ?
Premarket Notification for medical devices – PMN or 510(k)
Antibiotic Definition and classification
Antibiotic resitance and Antibiotic resistance mechanism
Vitamin D Details on FDA cautions on accurate dosage of Vitamin D
What is an antibody? what is monoclonal and polyclonal antibodies?
Terminologies In vaccine Production
Multi stage testing of Virus vaccine production
Testing of vaccines at different stages of production
TESTING FOR ADVENTITIOUS AGENTS CELL PROPERTIES IN VIRAL VACCINE PRODUCTION
Enzyme linked immunosorbent assay ELISA
http://whoguideline.blogspot.com/2010/04/terminalogy-and-their-explanations.html
Pharmaceutical Aseptic Manufacturing Process Terms , Terminology and Definitions.
http://whoguideline.blogspot.com/2010/02/pharmaceutical-aseptic-manufacturing.html
Here are some articles which will be useful for you in further understanding of aspects of sterile dosage form manufacturing and regulatory affairs and good manufacturing practice in
Types of validations in pharmaceutical manufacturing
Requirements of documents for validation of sterilisation process
How to investigate OOS out of specification results
Determination of Phenol coefficient of a disinfectant
Time limitations in sterile pharmaceuticals processing
Aspects of validation of manufacturing process in sterile pharmaceuticals
Controlling Pyrogens in injectable dosage forms
Media fill run process simulation aspects Validation of Aseptic Process and Sterilisation
New Drug Application (NDA) how to make a New Drug Application (NDA) to US FDA
How to make Investigational New Drug (IND) Application to US FDA
Drug applications submission to us fda Over the counter Drugs OTC drugs
BIOAVAILABILITY AND BIOEQUIVALENCE REQUIREMENTS
Electronic record in pharmaceutical manufacturing industry
Good manufacturing practice in pharmaceutical industry
Pharmaceutical industry pharmaceutical companies and FDA latest updates
Here is an interesting article on world wide pharmaceutical industry and making a carrier in one of pharmaceutical companies article on Pharmaceutical Industry pharmaceutical industry
Find a Job in Pharmaceutical Company
To Find Pharmaceutical jobs and make a Pharmaceutical careers see here pharmaceutical companies
Here are some interesting articles on Quality assurance systems for pharmaceutical company
1.Quality assurance in pharma industry
2.Quality by designe concept for pharmaceutical industry
3.Quality by designe concept in pharmaceutical industryan explanation